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Systematic reviews and meta-analysis are at the top of what is known as the “Evidence Pyramid”. As you move up the pyramid the amount of available evidence on a given topic decreases, but the relevancy and quality of that evidence increases. Systematic reviews and meta-analysis are considered to be the highest quality evidence on a clinical topic. However, you may not always be able to find the highest level of evidence to answer your question. You then need to consider moving down the pyramid. See definition of research study types
Source: “EBM Pyramid.” Digital Image. Eli M. Oboler Library, 27 May 2016